Closed-loop optogenetic intervention in mice
نویسندگان
چکیده
منابع مشابه
Closed-Loop and Activity-Guided Optogenetic Control
Advances in optical manipulation and observation of neural activity have set the stage for widespread implementation of closed-loop and activity-guided optical control of neural circuit dynamics. Closing the loop optogenetically (i.e., basing optogenetic stimulation on simultaneously observed dynamics in a principled way) is a powerful strategy for causal investigation of neural circuitry. In p...
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OBJECTIVE Controlling neural activity enables the possibility of manipulating sensory perception, cognitive processes, and body movement, in addition to providing a powerful framework for functionally disentangling the neural circuits that underlie these complex phenomena. Over the last decade, optogenetic stimulation has become an increasingly important and powerful tool for understanding neur...
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Dynamic oscillatory coherence is believed to play a central role in flexible communication between brain circuits. To test this communication-through-coherence hypothesis, experimental protocols that allow a reliable control of phase-relations between neuronal populations are needed. In this modeling study, we explore the potential of closed-loop optogenetic stimulation for the control of funct...
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Despite the high prevalence of stroke and epilepsy, both major sources of disability1–4, the underlying cellular and circuit mechanisms leading from stroke to epilepsy remain unknown, and injury-induced epilepsies often do not respond to existing treatments3,5. Identification of the neural circuits involved in injury-induced epilepsy is necessary to pinpoint the exact nature of the causally imp...
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This paper presents a distance protection test procedure by applying the Real-Time Digital Simulator (RTDS) of a power system. RTDS is a tool to design, develop, and test power-system protection. The RTDS enables real-time computation of electromagnetic phenomena with a calculation time step of even 50μs. The hardware allows the import and export of many signals from the simulator to an ext...
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ژورنال
عنوان ژورنال: Nature Protocols
سال: 2013
ISSN: 1754-2189,1750-2799
DOI: 10.1038/nprot.2013.080